Article

Glycerol metabolism triggers trypanosome differentiation into transmissible forms in mammalian tissue-like conditions

2025-05-26

Abstract excerpt

In the mammalian bloodstream, Trypanosoma brucei , the parasite responsible for sleeping sickness, proliferates as slender forms before undergoing quorum-sensing (QS)-mediated differentiation into cell cycle-arrested stumpy forms (stumpy-QS), a transition that regulates parasitaemia and primes parasites for tsetse fly transmission. Beyond the bloodstream, T. brucei also occupies extravascular, adipose-rich tissu...

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Literature Corpus work: fa3f889a-ac84-5419-8070-108807362466
DOI: 10.1101/2025.05.26.656071

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