Article

REST Promotes Pancreatic Ductal Adenocarcinoma Progression by Inhibiting NOXA1/ROS Pathway-Induced Cell Pyroptosis

2026-05-28

Abstract excerpt

<title>Abstract</title> <p> Inducing alternative programmed cell death is a promising strategy for apoptosis-resistant pancreatic ductal carcinoma (PDAC). The RE-1 silencing transcriptional repressor (REST) has been recognized to govern genesis of embryonic pancreas. Whether REST participates in regulating alternative programmed cell death of PDAC has not been revealed. In this study, we applied immunohistochemi...

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Literature Corpus work: e76c0bd4-28d5-5c45-8bfa-aa492dee2f76
DOI: 10.21203/rs.3.rs-9635765/v1

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