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The motor neuron disease mouse model hSOD1-G93A presents a non-canonical profile of senescence biomarkers in the spinal cord

2021-02-15

Abstract excerpt

<title>Abstract</title> <p>Recent evidence demonstrates a pathological role for senescent cells in Alzheimer’s and Parkinson’s diseases. The present study aimed to show senescence mechanisms including senescence-associated secretory phenotype (SASP) in the familial amyotrophic lateral sclerosis (ALS) transgenic mouse model hSOD1-G93A. We evaluated, as senescence biomarkers, the expression of p16 and p21 with reve...

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Literature Corpus work: e756a89e-51b0-5056-8fa8-18569893aec1
DOI: 10.21203/rs.3.rs-104871/v3

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