Article

Tissue-specificity of gene expression diverges slowly between orthologs, and rapidly between paralogs

2016-07-21

Abstract excerpt

The ortholog conjecture implies that functional similarity between orthologous genes is higher than between paralogs. It has been supported using levels of expression and Gene Ontology term analysis, although the evidence was rather weak and there were also conflicting reports. In this study on 12 species we provide strong evidence of high conservation in tissue-specificity between orthologs, in contrast to low co...

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Literature Corpus work: e745f075-478c-52e1-8c79-66a2c326fc1b
DOI: 10.1101/065086

Open publication

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