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Article

Tissue-driven hypothesis of genomic evolution and sequence-expression correlations.

Proceedings of the National Academy of Sciences of the United States of America - 20 Feb 2007

Gu Xun, Su Zhixi

Abstract excerpt

To maintain normal physiological functions, different tissues may have different developmental constraints on expressed genes. Consequently, the evolutionary tolerance for genomic evolution varies among tissues. Here, we formulate this argument as a "tissue-driven hypothesis" based on the stabilizing selection model. Moreover, several predicted genomic correlations are tested by the human-mouse microarray data....

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Identifiers

PMID: 17301236
DOI: 10.1073/pnas.0610797104
PMCID: PMC1815258

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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