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Article

How confident can we be that orthologs are similar, but paralogs differ?

Trends in genetics : TIG - 1 May 2009

Studer Romain A, Robinson-Rechavi Marc

Abstract excerpt

Homologous genes are classified into orthologs and paralogs, depending on whether they arose by speciation or duplication. It is widely assumed that orthologs share similar functions, whereas paralogs are expected to diverge more from each other. But does this assumption hold up on further examination? We present evidence that orthologs and paralogs are not so different in either their evolutionary rates or their...

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Identifiers

PMID: 19368988
DOI: 10.1016/j.tig.2009.03.004

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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