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Article

Mammalian housekeeping genes evolve more slowly than tissue-specific genes.

Molecular biology and evolution - 1 Feb 2004

Zhang Liqing, Li Wen-Hsiung

Abstract excerpt

Do housekeeping genes, which are turned on most of the time in almost every tissue, evolve more slowly than genes that are turned on only at specific developmental times or tissues? Recent large-scale gene expression studies enable us to have a better definition of housekeeping genes and to address the above question in detail. In this study, we examined 1581 human-mouse orthologous gene pairs for their patterns...

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PMID: 14595094
DOI: 10.1093/molbev/msh010

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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