Article

Virtual phenotypic screening discovers novel scaffolds inhibiting the PI3K/mTOR pathway

2026-06-14

Abstract excerpt

Phenotypic drug discovery has yielded many first-in-class small-molecule drugs by discovering modulators of disease phenotypes in physiologically relevant cellular systems. However, high-content phenotypic assays lack the ultra-high-throughput scalability of target-based screens. Recent advances in virtual screening present an opportunity to address this bottleneck, but have been limited to simple phenotypes like...

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Literature Corpus work: e73c48be-edef-5765-891d-4dbd8c8892b7
DOI: 10.64898/2026.06.10.731476

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