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Large scale compound selection guided by cell painting reveals activity cliffs and functional relationships.

Communications biology - 13 Jan 2026

Sanchez Maxime, Bourriez Nicolas, Bendidi Ihab, Cohen Ethan, Svatko Ivan, Del Nery Elaine, Tajmouati Hamza, Bollot Guillaume, Calzone Laurence, Genovesio Auguste

Abstract excerpt

Traditional structure-based pre-screen compound selection relies on the assumption that chemical similarity implies similar biological activity. This paradigm narrows the exploration of chemical space and often fails to account for functional convergence, where structurally diverse compounds act through distinct targets to produce similar phenotypic effects. As a result, compounds with therapeutic potential may...

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PMID: 41530519
DOI: 10.1038/s42003-025-09500-y
PMCID: PMC12901981

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CP

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

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