Virtual screening for small molecule pathway regulators by image profile matching

Abstract excerpt

Identifying chemical regulators of biological pathways is a time-consuming bottleneck in developing therapeutics and research compounds. Typically, thousands to millions of candidate small molecules are tested in target-based biochemical screens or phenotypic cell-based screens, both expensive experiments customized to each disease. Here, our uncustomized, virtual profile-based screening approach instead identifie...

Topics

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• Datasets as Topic
• Drug Discovery
• Drug Evaluation, Preclinical
• Gene Expression Profiling
• High-Throughput Screening Assays
• Phenotype
• Structure-Activity Relationship
• Transcriptome

Identifiers and source

Literature Corpus work

00aea00c-40e6-57c4-8a6a-f703bc31e648

DOI

10.1101/2021.07.29.454377