Article

PhenoScreen: A Dual-Space Contrastive Learning Framework-based Phenotypic Screening Method by Linking Chemical Perturbations to Cellular Morphology

2024-10-28

Abstract excerpt

Phenotypic drug discovery (PDD) screens compounds in cellular models that represent disease-relevant phenotypes, offering a compelling alternative to traditional target-based approaches. Unlike conventional methods, where compounds act on a single predefined target, PDD identifies compounds capable of exerting therapeutic effects through multiple targets and mechanisms. This makes PDD particularly valuable for dis...

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Literature Corpus work: c67ddd4a-64d4-513f-a75e-ea9ad3868319
DOI: 10.1101/2024.10.23.619752

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