Article

Asymmetrical dose-responses shape the evolutionary trade-off between antifungal resistance and nutrient use

2021-11-29

Abstract excerpt

Antimicrobial resistance is an emerging threat for public health. The success of resistance mutations depends on the trade-off between the benefits and costs they incur. This trade-off is largely unknown and uncharacterized for antifungals. Here, we systematically measure the effect of all amino acid substitutions in the yeast cytosine deaminase Fcy1, the target of the antifungal 5-FC (flucytosine). We identify ov...

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Literature Corpus work: e73383c9-54e7-5582-b8d2-e707e7e1740d
DOI: 10.1101/2021.11.29.469899

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