Article

Tertiary lymphoid structures induced by CXCL13-producing CD4 <sup>+</sup> T cells increase tumor infiltrating CD8 <sup>+</sup> T cells and B cells in ovarian cancer

2021-12-01

Abstract excerpt

<h4>Background</h4> Tertiary lymphoid structures (TLSs) are transient ectopic lymphoid aggregates whose formation might be caused by chronic inflammation states, such as cancer. The presence of TLS is associated with a favorable prognosis in most solid malignancies. The recognition of the relevance of TLS to cancer has led to a growing interest in TLS as an immunomodulatory target to enhance tumor immunity, altho...

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Literature Corpus work: e6e51f41-c2d0-5454-8ad3-817c28e5452c
DOI: 10.1101/2021.12.01.470493

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