Article

Detailed characterization of PD-1/PD-L1 and CTLA4 expression and tumor-infiltrating lymphocytes in yolk sac tumors

2022-06-22

Abstract excerpt

<h4>Background: </h4> Immune checkpoint blockade (ICB) is considered as a promising approach for cancer treatment. However, the potency of ICB therapy in yolk sac tumors (YSTs) has not been confirmed, and the comprehensive analysis of tumor immune microenvironment and the expression of PD-1/PD-L1 and CTLA4 were also not thoroughly evaluated. <h4>Methods: </h4>: Immunohistochemistry was performed in formalin-fixed,...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: a6e89ffb-896a-59bb-a0bc-63d5d25bc8f9
DOI: 10.21203/rs.3.rs-1765232/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Detailed characterization of PD-1/PD-L1 and CTLA4 expression and tumor-infiltrating lymphocytes in yolk sac tumorsDOI 10.21203/rs.3.rs-1765232/v1Read

Insights into tertiary lymphoid structures in the solid tumor microenvironment: anti-tumor mechanism, functional regulation, and immunotherapeutic strategiesSemantic proximity Read

B Cells and Tertiary Lymphoid Structures: Friends or Foes in Cancer Immunotherapy?Semantic proximity Read

The Immune landscape of pediatric solid tumorsSemantic proximity Read

Dysgerminoma germ cell tumors exhibit high expression of PD-L1 and are associated with high levels of tumor-infiltrating lymphocytes and a good patient prognosisSemantic proximity Read

Tertiary lymphoid structures induced by CXCL13-producing CD4 <sup>+</sup> T cells increase tumor infiltrating CD8 <sup>+</sup> T cells and B cells in ovarian cancerSemantic proximity Read

Immune profiling of pediatric germ cell tumors identifies key cell populations and novel therapeutic targetsSemantic proximity Read

Immune Checkpoint Inhibitors-Related Thyroid Dysfunction: Epidemiology, Clinical Presentation, Possible Pathogenesis, and Management.Semantic proximity Read

Yolk sac tumours revisited. A review of their many faces and namesSemantic proximity Read

Testicular sex cord–stromal tumors in mice with constitutive activation of PI3K and loss of PtenSemantic proximity Read

Tertiary lymphoid structures and B cells determine clinically relevant T cell phenotypes in ovarian cancer.Semantic proximity Read

Impact of the canine osteosarcoma tumor microenvironment on immune cell composition and gene expression profilesSemantic proximity Read

Tertiary lymphoid structures in cancerSemantic proximity Read