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Epigenetic targets to enhance antitumor immune response through the induction of tertiary lymphoid structures

25 Jan 2024

Abstract excerpt

Tertiary lymphoid structures (TLS) are ectopic lymphoid aggregates found in sites of chronic inflammation such as tumors and autoimmune diseases. The discovery that TLS formation at tumor sites correlated with good patient prognosis has triggered extensive research into various techniques to induce their formation at the tumor microenvironment (TME). One strategy is the exogenous induction of specific cytokines...

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PMID: 38333212
DOI: 10.3389/fimmu.2024.1348156

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