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Article

FcεRI: A Master Regulator of Mast Cell Functions

11 Feb 2022

Abstract excerpt

Mast cells (MCs) perform multiple functions thought to underlie different manifestations of allergies. Various aspects of antigens (Ags) and their interactions with immunoglobulin E (IgE) cause diverse responses in MCs. FcεRI, a high-affinity IgE receptor, deciphers the Ag-IgE interaction and drives allergic responses. FcεRI clustering is essential for signal transduction and, therefore, determines the quality of...

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PMID: 35203273
DOI: 10.3390/cells11040622

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