Article
The MHC class I binding proteins LIR-1 and LIR-2 inhibit Fc receptor-mediated signaling in monocytes.
European journal of immunology - 1 Nov 1998
Fanger N A, Cosman D, Peterson L, Braddy S C, Maliszewski C R, Borges L
Abstract excerpt
The MHC class I binding proteins leukocyte immunoglobulin-like receptor (LIR)-1 and -2 recognize a similar broad spectrum of HLA-A, -B and -C alleles but are differentially expressed in lymphocytes, monocytes, and dendritic cells. In monocytes, phosphorylation of LIR-1 and LIR-2 results in the bi...
Topics
- Alleles
- Animals
- Antigens, CD
- Calcium
- HLA Antigens
- Humans
- Intracellular Signaling Peptides and Proteins
- Leukocyte Immunoglobulin-like Receptor B1
- Monocytes
- Phosphorylation
- Protein Tyrosine Phosphatase, Non-Receptor Type 11
- Protein Tyrosine Phosphatase, Non-Receptor Type 6
- Protein Tyrosine Phosphatases
- Protein-Tyrosine Kinases
- Rabbits
- Receptors, Fc
- Receptors, Immunologic