Article

The Dopamine Receptor Antagonist TFP Prevents Phenotype Conversion and Improves Survival in Mouse Models of Glioblastoma

2019-12-10

Abstract excerpt

Glioblastoma (GBM) is the deadliest adult brain cancer and all patients ultimately succumb to the disease. Radiation therapy (RT) provides survival benefit of 6 months over surgery alone but these results have not improved in decades. We report that radiation induces a glioma-initiating cell phenotype and we have identified trifluoperazine (TFP) as a compound that interferes with this phenotype conversion. TFP cau...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: e6dd8ea5-68fd-5d77-ad25-74b7ce2480f3
DOI: 10.1101/870394

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

The Dopamine Receptor Antagonist TFP Prevents Phenotype Conversion and Improves Survival in Mouse Models of GlioblastomaDOI 10.1101/870394Read

The dopamine receptor antagonist trifluoperazine prevents phenotype conversion and improves survival in mouse models of glioblastoma.Semantic proximity Read

Synergistic Effects of the DRD2/3 Antagonist ONC201 and Radiation in GlioblastomaSemantic proximity Read

Targeting Radiation-Induced Glioma-Initiating Cells in Patient-Derived GlioblastomaSemantic proximity Read

Glioblastoma Standard of Care: Effects on Tumor Evolution and Reverse Translation in Preclinical ModelsSemantic proximity Read

Glioblastoma Standard of Care: Effects on Tumor Evolution and Reverse Translation in Preclinical ModelsSemantic proximity Read

Combined Treatment with Dopamine Receptor Antagonists and Radiation Creates a Metabolic Vulnerability in Mouse Models of GlioblastomaSemantic proximity Read

Core pathway mutations induce de-differentiation of murine astrocytes into glioblastoma stem cells that are sensitive to radiation but resistant to temozolomide.Semantic proximity Read

Design and Biological Activity of a Novel Brain Penetrant Urea Compound Against GlioblastomaSemantic proximity Read

Functional Characterization of Brain Tumor-Initiating Cells and Establishment of GBM Preclinical Models that Incorporate Heterogeneity, Therapy, and Sex DifferencesSemantic proximity Read

Ablation of neuropilin-1 improves the therapeutic response in conventional drug-resistant glioblastoma multiforme.Semantic proximity Read

YAP/TAZ Transcriptional Coactivators Create Therapeutic Vulnerability to Verteporfin in EGFR-mutant Glioblastoma.Semantic proximity Read

Alterations in Molecular Profiles Affecting Glioblastoma Resistance to Radiochemotherapy: Where Does the Good Go?Semantic proximity Read