Article

Synergistic Effects of the DRD2/3 Antagonist ONC201 and Radiation in Glioblastoma

2020-07-24

Abstract excerpt

<h4>Background</h4> Glioblastoma (GBM) is the deadliest of all brain cancers in adults. The current standard-of-care is surgery followed by radiotherapy and temozolomide, leading to a median survival time of only 15 months. GBM are organized hierarchically with a small number of glioma-initiating cells, responsible for therapy resistance and tumor recurrence, suggesting that targeting glioma-initiating cells coul...

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Literature Corpus work: 94e46b7e-c6f3-5702-b989-e03d628e6640
DOI: 10.1101/2020.07.23.218446

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