Article

Design and Biological Activity of a Novel Brain Penetrant Urea Compound Against Glioblastoma

2025-04-16

Abstract excerpt

Glioblastoma (GBM) remains the most lethal primary brain tumor, largely due to therapy-resistant glioma stem cells (GSCs) and the ability of non-stem cells to dedifferentiate under therapeutic pressure. We developed MXC-017, a novel urea-based compound that crosses the blood–brain-barrier, directly targets GSCs, and prevents radiation-induced GSC formation. Using click chemistry pull-down and mass spectrometr...

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Literature Corpus work: 0e083228-5e59-5398-bbd0-da0461d08ecf
DOI: 10.1101/2025.04.10.648292

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