Article
Ablation of neuropilin-1 improves the therapeutic response in conventional drug-resistant glioblastoma multiforme.
Oncogene - 1 Nov 2020
Angom Ramcharan Singh, Mondal Sujan Kumar, Wang Fei, Madamsetty Vijay Sagar, Wang Enfeng, Dutta Shamit K, Gulani Yash, Sarabia-Estrada Rachel, Sarkaria Jann N, Quiñones-Hinojosa Alfredo, Mukhopadhyay Debabrata
Abstract excerpt
Glioblastoma multiforme (GBM) is a highly proliferative and locally invasive cancer with poor prognosis and a high recurrence rate. Although anti-VEGF (vascular endothelial growth factor) therapy offers short-term benefit to GBM patients, this approach fails as the tumor develops into a more invasive and drug-resistant phenotype and ultimately recurs. Recently, both glioma stemlike cells (GSCs) and brain...
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