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Article

The dopamine receptor antagonist trifluoperazine prevents phenotype conversion and improves survival in mouse models of glioblastoma.

Proceedings of the National Academy of Sciences of the United States of America - 19 May 2020

Bhat Kruttika, Saki Mohammad, Vlashi Erina, Cheng Fei, Duhachek-Muggy Sara, Alli Claudia, Yu Garrett, Medina Paul, He Ling, Damoiseaux Robert, Pellegrini Matteo, Zemke Nathan R, Nghiemphu Phioanh Leia, Cloughesy Timothy F, Liau Linda M, Kornblum Harley I, Pajonk Frank

Abstract excerpt

Glioblastoma (GBM) is the deadliest adult brain cancer, and all patients ultimately succumb to the disease. Radiation therapy (RT) provides survival benefit of 6 mo over surgery alone, but these results have not improved in decades. We report that radiation induces a glioma-initiating cell phenotype, and we have identified trifluoperazine (TFP) as a compound that interferes with this phenotype conversion. TFP...

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Identifiers

PMID: 32358191
DOI: 10.1073/pnas.1920154117
PMCID: PMC7245100

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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