Article

Single-Nucleus Transcriptomics Identifies a C5AR1-Driven, Hypoxia-Responsive Microglial State in the Human ALS Spinal Cord

2026-04-06

Abstract excerpt

<title>Abstract</title> <p>In this study, single-nucleus transcriptomic profiling of 62,711 nuclei from the human lumbar spinal cord was employed to resolve disease-specific immune heterogeneity in Amyotrophic Lateral Sclerosis (ALS). While neuroinflammation driven by microglial activation is a recognized driver of motor neuron attrition, the molecular checkpoints governing the transition of human microglia into...

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Literature Corpus work: e6d1347b-6d59-50b3-a043-4b3f74f4c889
DOI: 10.21203/rs.3.rs-9226186/v1

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