Article

Trans-generational maintenance of mitochondrial DNA integrity in oocytes during early folliculogenesis

2025-01-02

Abstract excerpt

Mutations in mitochondrial DNA (mtDNA) can lead to mitochondrial and cellular dysfunction. However, recent studies suggest that there is purifying selection against mutant mtDNAs during transgenerational transmission. We investigated the mtDNA dynamics during ovarian follicle development. Using base-editing, we generated mice harboring a 3177 G>A mutation corresponding to the human Leber hereditary optic neuropath...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: e6cfceb5-925d-5d90-b758-bbe688b841a5
DOI: 10.1101/2025.01.02.631059

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Trans-generational maintenance of mitochondrial DNA integrity in oocytes during early folliculogenesisDOI 10.1101/2025.01.02.631059Read

Selective elimination of mitochondrial mutations in the germline by genome editing.Semantic proximity Read

Age-related accumulation of de novo mitochondrial mutations in mammalian oocytes and somatic tissues.Semantic proximity Read

Differences in Strength and Timing of the mtDNA Bottleneck between Zebrafish Germline and Non-germline Cells.Semantic proximity Read

Replication Errors Made During Oogenesis Lead to Detectable De Novo mtDNA Mutations in Zebrafish Oocytes with a Low mtDNA Copy Number.Semantic proximity Read

Consequences of zygote injection and germline transfer of mutant human mitochondrial DNA in mice.Semantic proximity Read

Delivery of mtZFNs into Early Mouse Embryos.Semantic proximity Read

A method for mutagenesis of mouse mtDNA and a resource of mouse mtDNA mutations for modeling human pathological conditions.Semantic proximity Read

Avoiding Extinction: Recent Advances in Understanding Mechanisms of Mitochondrial DNA Purifying Selection in the Germline.Semantic proximity Read

Germline mitochondrial DNA mutations aggravate ageing and can impair brain development.Semantic proximity Read

Maternally transmitted mitochondrial DNA mutations can reduce lifespan.Semantic proximity Read

Maternal age enhances purifying selection on pathogenic mutations in complex I genes of mammalian mtDNA.Semantic proximity Read

Keeping mtDNA in shape between generations.Semantic proximity Read