Article
Differences in Strength and Timing of the mtDNA Bottleneck between Zebrafish Germline and Non-germline Cells.
Cell reports - 19 Jul 2016
Otten Auke B C, Theunissen Tom E J, Derhaag Josien G, Lambrichs Ellen H, Boesten Iris B W, Winandy Marie, van Montfoort Aafke P A, Tarbashevich Katsiaryna, Raz Erez, Gerards Mike, Vanoevelen Jo M, van den Bosch Bianca J C, Muller Marc, Smeets Hubert J M
Abstract excerpt
We studied the mtDNA bottleneck in zebrafish to elucidate size, timing, and variation in germline and non-germline cells. Mature zebrafish oocytes contain, on average, 19.0 × 10(6) mtDNA molecules with high variation between oocytes. During embryogenesis, the mtDNA copy number decreases to ∼170 mtDNA molecules per primordial germ cell (PGC), a number similar to that in mammals, and to ∼50 per non-PGC. These occur...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.