Article
Consequences of zygote injection and germline transfer of mutant human mitochondrial DNA in mice.
Proceedings of the National Academy of Sciences of the United States of America - 20 Oct 2015
Yu Hong, Koilkonda Rajeshwari D, Chou Tsung-Han, Porciatti Vittorio, Mehta Arpit, Hentall Ian D, Chiodo Vince A, Boye Sanford L, Hauswirth William W, Lewin Alfred S, Guy John
Abstract excerpt
Considerable evidence supports mutations in mitochondrial genes as the cause of maternally inherited diseases affecting tissues that rely primarily on oxidative energy metabolism, usually the nervous system, the heart, and skeletal muscles. Mitochondrial diseases are diverse, and animal models currently are limited. Here we introduced a mutant human mitochondrial gene responsible for Leber hereditary optic...
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