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Article

A method for mutagenesis of mouse mtDNA and a resource of mouse mtDNA mutations for modeling human pathological conditions.

Nucleic acids research - 19 May 2015

Fayzulin Rafik Z, Perez Michael, Kozhukhar Natalia, Spadafora Domenico, Wilson Glenn L, Alexeyev Mikhail F

Abstract excerpt

Mutations in human mitochondrial DNA (mtDNA) can cause mitochondrial disease and have been associated with neurodegenerative disorders, cancer, diabetes and aging. Yet our progress toward delineating the precise contributions of mtDNA mutations to these conditions is impeded by the limited availability of faithful transmitochondrial animal models. Here, we report a method for the isolation of mutations in mouse...

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Identifiers

PMID: 25820427
DOI: 10.1093/nar/gkv140
PMCID: PMC4482060

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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