Article

REST is a major negative regulator of endocrine differentiation during pancreas organogenesis

2021-03-17

Abstract excerpt

<h4>SUMMARY</h4> Understanding genomic regulatory mechanisms of pancreas differentiation is relevant to the pathophysiology of diabetes mellitus, and to the development of replacement therapies. Numerous transcription factors promote β cell differentiation, although less is known about negative regulators. Earlier epigenomic studies suggested that the transcriptional repressor REST could be a suppressor of endocr...

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Literature Corpus work: e6c8c57f-ff71-5435-93c8-a10f45f8a257
DOI: 10.1101/2021.03.17.435876

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