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Unbiased transcription factor CRISPR screen identifies ZNF800 as master repressor of enteroendocrine differentiation

26 Oct 2023

Abstract excerpt

Enteroendocrine cells (EECs) are hormone-producing cells residing in the epithelium of stomach, small intestine (SI), and colon. EECs regulate aspects of metabolic activity, including insulin levels, satiety, gastrointestinal secretion, and motility. The generation of different EEC lineages is not completely understood. In this work, we report a CRISPR knockout screen of the entire repertoire of transcription...

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PMID: 37883554
DOI: 10.1126/science.adi2246

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