White spotting phenotype induced by targeted REST disruption during neural crest specification to a melanocyte cell lineage.

doi:10.1111/gtc.12235

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Article

White spotting phenotype induced by targeted REST disruption during neural crest specification to a melanocyte cell lineage.

Genes to cells : devoted to molecular & cellular mechanisms - 1 May 2015

Aoki Hitomi, Hara Akira, Kunisada Takahiro

Abstract excerpt

Neural crest cells (NCCs) emerge from the dorsal region of the neural tube of vertebrate embryos and have the pluripotency to differentiate into both neuronal and non-neuronal lineages including melanocytes. Rest, also known as NRSF (neuro-restrictive silencer factor), is a regulator of neuronal development and function and suggested to be involved in the lineage specification of NCCs. However, further...

Topics

Animals
Cell Differentiation
Cell Lineage
Gene Expression
Gene Targeting
Genes, Reporter
Melanocytes
Mice
Mice, Knockout
Neural Crest
Phenotype
Repressor Proteins
Skin Pigmentation

Source

Open in PubMed

Identifiers

PMID: 25818501
DOI: 10.1111/gtc.12235

Genes

REST

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026.

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