Article
Genetic determinants of inherited susceptibility to hypercholesterolemia - a comprehensive literature review.
Lipids in health and disease - 2 Jun 2017
Paththinige C S, Sirisena N D, Dissanayake Vhw
Abstract excerpt
Hypercholesterolemia is a strong determinant of mortality and morbidity associated with cardiovascular diseases and a major contributor to the global disease burden. Mutations in four genes (LDLR, APOB, PCSK9 and LDLRAP1) account for the majority of cases with familial hypercholesterolemia. However, a substantial proportion of adults with hypercholesterolemia do not have a mutation in any of these four genes....
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.