Article

Luminal Vascular Dysfunction Drives Rapid Blood Brain Barrier Injury in Hyperglycemic Stroke: Key Roles for Luminal Glycocalyx and Complement

2025-06-30

Abstract excerpt

<h4>Background</h4> Acute hyperglycemia affects approximately 40% of stroke patients and is associated with worse outcomes. The underlying mechanisms linking this metabolic stress to stroke-induced brain injury remains unclear, and effective therapies are lacking. <h4>Methods</h4> In a mouse model of acute hyperglycemic stroke, luminal disruption, blood-brain barrier (BBB) leakage, neurological deficit, motor fu...

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Literature Corpus work: e6c63359-6a6a-5efa-ac63-281d2289aa6c
DOI: 10.1101/2025.06.26.661858

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