Article

Fatty acid binding protein-8 (FABP8/PMP2) reveals molecular heterogeneity of myelin sheaths in the human CNS

2026-06-10

Abstract excerpt

Myelin is classically viewed as a uniform axon-insulating membrane, yet its molecular composition may differ between species and even within one species. Fatty acid binding protein-8 (FABP8/PMP2) was previously identified in CNS myelin of humans but not mice. Here we show that FABP8/PMP2 is a defining feature of CNS myelin in humans and old-world-monkeys, but absent from CNS myelin in other mammals, indicating evo...

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Identifiers and source

Literature Corpus work: e6795073-6bc3-57d1-b4cc-ae0a8a62cd2d
DOI: 10.64898/2026.06.09.730898

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