Article

Analysis of context-specific KRAS-effectors (sub)complexes in Caco-2 cells

2022-08-15

Abstract excerpt

Ras is a key switch controlling cell behavior. In the GTP-bound form, Ras interacts with numerous effectors in a mutually exclusive manner, where individual Ras-effectors are likely part of larger cellular (sub)complexes. The molecular details of these (sub)complexes and their alteration in specific contexts is not understood. Focusing on KRAS, we performed affinity purification (AP)-mass spectrometry (MS) experim...

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Literature Corpus work: e6721450-4a72-554a-9f1b-53392317ace5
DOI: 10.1101/2022.08.15.503960

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