Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Analysis of context-specific KRAS-effector (sub)complexes in Caco-2 cells.

Life science alliance - 1 May 2023

Ternet Camille, Junk Philipp, Sevrin Thomas, Catozzi Simona, Wåhlén Erik, Heldin Johan, Oliviero Giorgio, Wynne Kieran, Kiel Christina

Abstract excerpt

Ras is a key switch controlling cell behavior. In the GTP-bound form, Ras interacts with numerous effectors in a mutually exclusive manner, where individual Ras-effectors are likely part of larger cellular (sub)complexes. The molecular details of these (sub)complexes and their alteration in specific contexts are not understood. Focusing on KRAS, we performed affinity purification (AP)-mass spectrometry (MS)...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Caco-2 Cells
Share to Genes, ras

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Mutation

Share to Proto-Oncogene Proteins p21(ras)

Share to Signal Transduction

Source

Open in PubMed Open full text

Identifiers

PMID: 36894174
DOI: 10.26508/lsa.202201670
PMCID: PMC9998658

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Analysis of context-specific KRAS-effector (sub)complexes in Caco-2 cells.PMID 36894174Read ↗

Analysis of context-specific KRAS-effectors (sub)complexes in Caco-2 cellsSemantic proximity Read ↗

Extensive rewiring of the EGFR network in colorectal cancer cells expressing transforming levels of KRASG13D.Semantic proximity Read ↗

A Comparative Analysis of Individual RAS Mutations in Cancer BiologySemantic proximity Read ↗

Proteomic Mapping of the Interactome of KRAS Mutants Identifies New Features of RAS Signalling Networks and the Mechanism of Action of SotorasibSemantic proximity Read ↗

The Ins and Outs of RAS Effector Complexes.Semantic proximity Read ↗

Oncogenic mutations of KRAS modulate its turnover by the CUL3/LZTR1 E3 ligase complex.Semantic proximity Read ↗

Interplay Between KRAS and LZTR1 Protein Turnover, Controlled by CUL3/LZTR1 E3 Ubiquitin Ligase, is Disrupted by KRAS MutationsSemantic proximity Read ↗

Common and mutation specific phenotypes of KRAS and BRAF mutations in colorectal cancer cells revealed by integrative -omics analysis.Semantic proximity Read ↗

Profiling the kinome in oncogenic RAS mutant cellsSemantic proximity Read ↗

Mechanistic Foundations of KRAS‐Driven Tumor Ecosystems: Integrating Crosstalk among Immune, Metabolic, Microbial, and Stromal MicroenvironmentSemantic proximity Read ↗

Defining and targeting adaptations to oncogenic KRAS <sup>G12C</sup> inhibition using quantitative temporal proteomicsSemantic proximity Read ↗

KRAS G12C and KRAS G12D respond to lipid metabolism in an allele-specific manner.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.