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Intratumoral administration of mRNA COVID-19 vaccine delays melanoma growth in mice

13 Feb 2025

Abstract excerpt

Immunotherapies are effective for cancer treatment but are limited in ‘cold’ tumor microenvironments due to a lack of infiltrating CD8 + T cells, key players in the anti-cancer immune response. The onset of the COVID-19 pandemic sparked the widespread use of mRNA-formulated vaccines and is well documented that vaccination induces a Th1-skewed immune response. Here, we evaluated the effects of an intratumoral...

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PMID: 39948424
DOI: 10.1038/s41598-025-89930-0

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