Article

Combination of mutations in genes controlling DNA repair and high mutational load plays a prognostic role in pancreatic ductal adenocarcinoma (PDAC): a retrospective real-life study in Sardinian population

2024-01-03

Abstract excerpt

<title>Abstract</title> <p>Background Patients with pancreatic ductal adenocarcinoma (PDCA) carrying impaired mismatch repair mechanisms seem to have an outcome advantage under treatment with conventional chemotherapy, whereas the role for the tumor mutation burden on prognosis is controversial. In this study, we evaluated the prognostic role of the mutated genes involved in genome damage repair in a real-life s...

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Literature Corpus work: e6351976-1ecb-57c9-b8af-688e8361c4ca
DOI: 10.21203/rs.3.rs-3818206/v1

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