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Article

The germline/somatic DNA damage repair gene mutations modulate the therapeutic response in Chinese patients with advanced pancreatic ductal adenocarcinoma.

Journal of translational medicine - 12 Jul 2021

Shui Lin, Li Xiaofen, Peng Yang, Tian Jiangfang, Li Shuangshuang, He Du, Li Ang, Tian Bole, Li Mao, Gao Heli, An Ning, Yi Cheng, Cao Dan

Abstract excerpt

BACKGROUND: Pancreatic ductal adenocarcinoma (PDAC) is a fatal disease with molecular heterogeneity, inducing differences in biological behavior, and therapeutic strategy. NGS profiles of pathogenic alterations in the Chinese PDAC population are limited. We conducted a retrospective study to investigate the predictive role of DNA damage repair (DDR) mutations in precision medicine. METHODS: The NGS profiles were...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 34247626
DOI: 10.1186/s12967-021-02972-6
PMCID: PMC8273977

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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