Article
Combination of mutations in genes controlling DNA repair and high mutational load plays a prognostic role in pancreatic ductal adenocarcinoma (PDAC): a retrospective real-life study in Sardinian population.
Journal of translational medicine - 27 Jan 2024
Sini Maria Cristina, Doro Maria Grazia, Frogheri Laura, Zinellu Angelo, Paliogiannis Panagiotis, Porcu Alberto, Scognamillo Fabrizio, Delogu Daniele, Santeufemia Davide Adriano, Persico Ivana, Palomba Grazia, Maestrale Giovanni Battista, Cossu Antonio, Palmieri Giuseppe
Abstract excerpt
BACKGROUND: Patients with pancreatic ductal adenocarcinoma (PDCA) carrying impaired mismatch repair mechanisms seem to have an outcome advantage under treatment with conventional chemotherapy, whereas the role for the tumor mutation burden on prognosis is controversial. In this study, we evaluated the prognostic role of the mutated genes involved in genome damage repair in a real-life series of PDAC patients in a...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.