Nix induced mitochondrial fission, mitophagy, and myocyte insulin resistance are abrogated by PKA phosphorylation

Abstract excerpt

Lipotoxicity is a form of cellular stress caused by the accumulation of lipids resulting in mitochondrial dysfunction and insulin resistance in muscle. Previously, we demonstrated that the mitophagy receptor Nix is responsive to lipotoxicity and accumulates in response to diacylglycerols induced by high-fat (HF) feeding. In addition, previous studies have implicated autophagy and mitophagy in muscle insulin sensit...

Topics

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• Autophagy in Disease and Therapy
• Calcium signaling and nucleotide metabolism
• Cannabis and Cannabinoid Research
• Diet, Metabolism, and Disease
• Liver Disease Diagnosis and Treatment
• Metabolism, Diabetes, and Cancer
• Mitochondrial Function and Pathology
• Pancreatic function and diabetes

Identifiers and source

Literature Corpus work

7d975b27-e62c-565e-8923-0311a2ac5908

DOI

10.1101/825828