Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Klotho Stabilizes the Podocyte Actin Cytoskeleton in Idiopathic Membranous Nephropathy through Regulating the TRPC6/CatL Pathway

1 Jan 2024

Abstract excerpt

INTRODUCTION: The aim of this study was to explore the renoprotective effects of Klotho on podocyte injury mediated by complement activation and autoantibodies in idiopathic membranous nephropathy (IMN). METHODS: Rat passive Heymann nephritis (PHN) was induced as an IMN model. Urine protein levels, serum biochemistry, kidney histology, and podocyte marker levels were assessed. In vitro, sublytic podocyte injury...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Chronic Kidney Disease and Diabetes
Share to Parathyroid Disorders and Treatments
Share to Renal Diseases and Glomerulopathies

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 38330925
DOI: 10.1159/000537732

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Klotho Stabilizes the Podocyte Actin Cytoskeleton in Idiopathic Membranous Nephropathy through Regulating the TRPC6/CatL PathwayPMID 38330925Read ↗

Role of Transient Receptor Potential Canonical Channel 6 (TRPC6) in Diabetic Kidney Disease by Regulating Podocyte Actin Cytoskeleton RearrangementSemantic proximity Read ↗

Podocyte injury and targeting therapy: an updateSemantic proximity Read ↗

Crk1/2 and CrkL form a hetero-oligomer and functionally complement each other during podocyte morphogenesis.Semantic proximity Read ↗

Impact of klotho on the expression of SRGAP2a in podocytes in diabetic nephropathySemantic proximity Read ↗

Cytoskeleton Rearrangement in Podocytopathies: An UpdateSemantic proximity Read ↗

Nck Links Nephrin to Actin in Kidney PodocytesSemantic proximity Read ↗

Inhibition of TRPC6 channels ameliorates renal fibrosis and contributes to renal protection by soluble klotho.Semantic proximity Read ↗

TRPC Channels in Proteinuric Kidney DiseasesSemantic proximity Read ↗

Targeting the podocyte cytoskeleton: from pathogenesis to therapy in proteinuric kidney diseaseSemantic proximity Read ↗

Nephropathic Cystinosis: Pathogenic Roles of Inflammation and Potential for New TherapiesSemantic proximity Read ↗

Matrix Protein Tenascin-C Promotes Kidney Fibrosis via STAT3 activation in Response to Tubular InjurySemantic proximity Read ↗

A critical role of the podocyte cytoskeleton in the pathogenesis of glomerular proteinuria and autoimmune podocytopathiesSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.