Article
Epithelial and interstitial Notch1 activity contributes to the myofibroblastic phenotype and fibrosis.
Cell communication and signaling : CCS - 12 Nov 2019
Hong Weilong, Zhang Ge, Lu Hong, Guo Yangyang, Zheng Shizhang, Zhu Hengyue, Xiao Yanyi, Papa Akuetteh Percy David, Wu Cunzao, Sun Linxiao, Chen Bicheng, Bai Yongheng
Abstract excerpt
BACKGROUND: Notch1 signalling is a stem-cell-related pathway that is essential for embryonic development, tissue regeneration and organogenesis. However, the role of Notch1 in the formation of myofibroblasts and fibrosis in kidneys following injury remains unknown. METHODS: The activity of Notch1 signalling was evaluated in fibrotic kidneys in CKD patients and in ureteral obstructive models in vivo and in...
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