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Article

Protective role of renal proximal tubular alpha-synuclein in the pathogenesis of kidney fibrosis.

Nature communications - 23 Apr 2020

Bozic Milica, Caus Maite, Rodrigues-Diez Raul R, Pedraza Neus, Ruiz-Ortega Marta, Garí Eloi, Gallel Pilar, Panadés Maria José, Martinez Ana, Fernández Elvira, Valdivielso José Manuel

Abstract excerpt

Kidney fibrosis is a highly deleterious process and a final manifestation of chronic kidney disease. Alpha-(α)-synuclein (SNCA) is an actin-binding neuronal protein with various functions within the brain; however, its role in other tissues is unknown. Here, we describe the expression of SNCA in renal epithelial cells and demonstrate its decrease in renal tubules of murine and human fibrotic kidneys, as well as...

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Identifiers

PMID: 32327648
DOI: 10.1038/s41467-020-15732-9
PMCID: PMC7181766

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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