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Tumor <i>NLRP3</i> Amplification Promotes Immunotherapy Resistance by Suppressing MHC Class I Expression

2025-10-07

Abstract excerpt

Immunotherapy resistance remains a major challenge in immuno-oncology. We have previously demonstrated that a tumor-intrinsic NLRP3 inflammasome signaling pathway promotes adaptive immunotherapy resistance by inducing the recruitment of granulocytic myeloid-derived suppressor cells. We now confirm that elevated tumor NLRP3 signaling activity correlates with checkpoint inhibitor resistance in several independent co...

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Literature Corpus work
44d20eee-faee-5413-ad93-be8bbc738ea0
DOI
10.1101/2025.10.06.25337175
Open publication

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Tumor <i>NLRP3</i> Amplification Promotes Immunotherapy Resistance by Suppressing MHC Class I ExpressionDOI 10.1101/2025.10.06.25337175
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