Development and application of nbLIBRA-seq for high-throughput discovery of antigen-specific nanobodies

Abstract excerpt

<h4>ABSTRACT</h4> Nanobodies are of high interest in many fields of medicine and biotechnology due to their high stability, tissue penetration, and engineering adaptability compared to monoclonal antibodies. However, nanobody discovery has been limited by technologies that rely on laborious library generation, panning, and clone screening techniques. Here, we demonstrate the successful adaptation of Linking B-Cel...

Topics

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• Antibodies, Viral
• Antigens, Viral
• CAR-T cell therapy research
• COVID-19
• COVID-19 Vaccines
• Germinal Center
• Monoclonal and Polyclonal Antibodies Research
• T-cell and B-cell Immunology

Identifiers and source

Literature Corpus work

e5cce389-66ad-52e6-97be-ff610b27713d

DOI

10.64898/2025.12.30.697047