miRNA gene mutations commonly disrupt the proper functioning of miRNA genes

Abstract excerpt

<title>Abstract</title> <p>A growing number of mutations are being identified in the noncoding genome, including miRNA genes. However, little is known about the consequences of these mutations and how harmful they are to the functioning of miRNA genes. To evaluate the effects of miRNA gene mutations, we took advantage of a large collection of somatic mutations identified in miRNA genes in > 10K TCGA cancer sample...

Topics

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• RNA, Neoplasm
• Blotting, Northern
• Gene Expression Regulation, Neoplastic
• MicroRNAs
• Mutation
• Neoplasms
• Nucleic Acid Conformation
• Reverse Transcriptase Polymerase Chain Reaction

Identifiers and source

Literature Corpus work

e910d194-ab47-5c72-9bf0-69adb4775569

DOI

10.21203/rs.3.rs-7029847/v1