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Article

A pan-cancer atlas of somatic mutations in miRNA biogenesis genes.

Nucleic acids research - 25 Jan 2021

Galka-Marciniak Paulina, Urbanek-Trzeciak Martyna Olga, Nawrocka Paulina Maria, Kozlowski Piotr

Abstract excerpt

It is a well-known and intensively studied phenomenon that the levels of many miRNAs are differentiated in cancer. miRNA biogenesis and functional expression are complex processes orchestrated by many proteins cumulatively called miRNA biogenesis proteins. To characterize cancer somatic mutations in the miRNA biogenesis genes and investigate their potential impact on the levels of miRNAs, we analyzed whole-exome...

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PMID: 33406242
DOI: 10.1093/nar/gkaa1223
PMCID: PMC7826265

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Source receipt: pubmed, retrieved 7 Sept 2026.

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