Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Increased Expression of Interleukin-1 Receptor Characterizes Anti-estrogen-Resistant ALDH+ Breast Cancer Stem Cells

23 Jul 2020

Abstract excerpt

Estrogen-receptor-positive breast tumors are treated with anti-estrogen (AE) therapies but frequently develop resistance. Cancer stem cells (CSCs) with high aldehyde dehydrogenase activity (ALDH + cells) are enriched following AE treatment. Here, we show that the interleukin-1β (IL-1β) signaling pathway is activated in ALDH + cells, and data from single cells reveals that AE treatment selects for IL-1 receptor...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cancer Cells and Metastasis
Share to Cancer, Hypoxia, and Metabolism
Share to Cancer, Stress, Anesthesia, and Immune Response

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 32707076
DOI: 10.1016/j.stemcr.2020.06.020

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Increased Expression of Interleukin-1 Receptor Characterizes Anti-estrogen-Resistant ALDH+ Breast Cancer Stem CellsPMID 32707076Read ↗

A dormant sub-population expressing interleukin-1 receptor characterises anti-estrogen resistant ALDH+ breast cancer stem cellsSemantic proximity Read ↗

Identification of Distinct Breast Cancer Stem Cell Populations Based on Single-Cell Analyses of Functionally Enriched Stem and Progenitor Pools.Semantic proximity Read ↗

ALDH1A1 in breast cancer: A prospective target to overcome therapy resistance (Review)Semantic proximity Read ↗

The role of the aryl hydrocarbon receptor in the development of cells with the molecular and functional characteristics of cancer stem-like cellsSemantic proximity Read ↗

ALDHHigh Breast Cancer Stem Cells Exhibit a Mesenchymal-Senescent Hybrid Phenotype, with Elevated Metabolic and Migratory Activities.Semantic proximity Read ↗

ALDH1 is a marker of normal and malignant human mammary stem cells and a predictor of poor clinical outcome.Semantic proximity Read ↗

A ‘one-two punch’ therapy strategy to target chemoresistance in estrogen receptor positive breast cancerSemantic proximity Read ↗

Targeting Aldehyde Dehydrogenase Cancer Stem Cells in Ovarian CancerSemantic proximity Read ↗

Heterogeneity of normal human breast stem and progenitor cells as revealed by transcriptional profilingSemantic proximity Read ↗

Heterogeneity of Human Breast Stem and Progenitor Cells as Revealed by Transcriptional Profiling.Semantic proximity Read ↗

Role of IGF1R in Breast Cancer Subtypes, Stemness, and Lineage DifferentiationSemantic proximity Read ↗

ALDH1-Positive Cancer Stem Cells Predict Engraftment of Primary Breast Tumors and Are Governed by a Common Stem Cell ProgramSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.