Identification and characterization of non-canonical azole antifungal resistance pathways in Aspergillus fumigatus.

doi:10.1128/mbio.01723-26

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Article

Identification and characterization of non-canonical azole antifungal resistance pathways in Aspergillus fumigatus.

mBio - 9 Sept 2026

Delbaje Endrews, Ribeiro Matheus Mertz, Bitencourt Ricardo de Oliveira Barbosa, Lagrou Katrien, Hubka Vit, Pontes Laís, Schreiber Angélica Zaninelli, Robbins Nicole, Cowen Leah E, Dos Reis Thaila Fernanda, Goldman Gustavo H

Abstract excerpt

Human fungal infections, especially those caused by Aspergillus fumigatus, pose a significant global health threat, particularly in immunocompromised individuals. Azole antifungals are the primary treatment for this pathogen; however, the prevalence of azole-resistant A. fumigatus strains is steadily increasing. Mutations in cyp51A, which encodes an enzyme involved in ergosterol biosynthesis and the molecular...

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Topics

Aspergillus fumigatus
Drug Resistance, Fungal
Antifungal Agents
Azoles
Fungal Proteins

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Humans

Cytochrome P-450 Enzyme System

Aspergillosis

Microbial Sensitivity Tests

Mutation

Gene Expression Profiling

Whole Genome Sequencing

Genetic Variation

Source

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Identifiers

PMID: 42615624
DOI: 10.1128/mbio.01723-26
PMCID: PMC13556210

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