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Article

Next generation exome sequencing of paediatric inflammatory bowel disease patients identifies rare and novel variants in candidate genes.

Gut - 1 Jul 2013

Christodoulou Katja, Wiskin Anthony E, Gibson Jane, Tapper William, Willis Claire, Afzal Nadeem A, Upstill-Goddard Rosanna, Holloway John W, Simpson Michael A, Beattie R Mark, Collins Andrew, Ennis Sarah

Abstract excerpt

BACKGROUND: Multiple genes have been implicated by association studies in altering inflammatory bowel disease (IBD) predisposition. Paediatric patients often manifest more extensive disease and a particularly severe disease course. It is likely that genetic predisposition plays a more substantial role in this group. OBJECTIVE: To identify the spectrum of rare and novel variation in known IBD susceptibility genes...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Open in PubMed Open full text

Identifiers

PMID: 22543157
DOI: 10.1136/gutjnl-2011-301833
PMCID: PMC3686259

Genes

NOD2
BACH2
ERAP2
GSDMB

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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